Inflammation and Immunology

Pfizer is a global leader in discovering and developing medicines for patients suffering from chronic immune diseases. Pfizer is committed to the discovery and development of novel therapeutics to help patients living with immune-inflammatory diseases. Pfizer Inflammation & Immunology is focused on discovering and developing the next generation of therapies for immune- mediated diseases. Pfizer is interested in entering into strategic relationships with innovative collaborators to develop novel and differentiated therapies for autoimmune diseases.

We are interested in establishing alliances to develop therapeutics, expand disease biology understanding, and identify biomarkers that impact three main areas:

• Rheumatology
  • Rheumatoid Arthritis
  • Systemic / Cutaneous Lupus Erythematosus
  • Lupus Nephritis
  • Scleroderma, localized and systemic
  • Systemic Sclerosis
  • yositis
  • jogren's Syndrome
  • Vasculitis
  • Giant Cell Arteritis
  • Rare rheumatologic diseases
  • Spondyloarthropathies
• Gastroenterology/Hepatology
  • Inflammatory Bowel Disease
  • F4 Non-Alcoholic Steatohepatitis
  • Fibrosing / Stricturing Crohn’s Disease
  • Autoimmune Hepatitis
  • Refractory Celiac
  • Eosinophilic Esophagitis
  • Systemic aspects of food allergy
• Medical Dermatology
  • Atopic Dermatitis
  • Alopecia Areata
  • Vitiligo
  • Hidradenitis Suppurativa
  • Chronic Spontaneous Urticaria
  • Pruritis indications: Lichen Sclerosus, Seborrheic / Perioral Dermatitis, Chronic Hand Eczema, Prurigo Nodularis
  • Bullous Pemphigoid,
  • Pemphigus Vulgaris
• Non-GI/Hepatology Fibrotic Diseases
• Other indications with high unmet need that are related to those above

Specific areas of interest include:

• Cytokines and their signaling pathways
• Adaptive Immunity, Lymphocyte biology including Th17 lymphocytes
• Regulatory cells and Tolerance induction
• Host-microbial interactions and microbiome with an interest in epithelial barrier
• Leukocyte metabolism
• Innate Immunity and Innate Lymphoid Cell biology
• Oxidative stress modulators
• Pan anti-fibrotics
• Novel methods to target pathogenic inflammatory fibroblast populations
• Technology platforms and products to help understand patient segmentation in the disease areas of interest and develop precision medicine strategies for innovative portfolio products
• Technology platforms and products that allow for greater tissue and cell specific delivery

Not actively seeking partnering opportunities in:

• TNFα, IL-1ß targeting biologics
• B cell depleting biologics
• Corticosteroids