Target Sciences

Target Sciences (TS) is a genomics partner line with expertise in Human Genetics, Functional Genomics, Computational Biology, and Diagnostics. TS is focused on Pfizer R&D in diagnostics development as well as target discovery and validation of first in class targets with compelling human-based confidence in rationale.

We are interested in establishing alliances to develop and access:

• Highly characterized patient cohorts for genetic studies in diseases of interest to Pfizer
  • Extreme phenotypes
  • Disease progression
  • Patient sub-types
  • Underrepresented ancestry patient cohorts
  • Specific areas of interest, in addition to Pfizer’s core disease areas, include fibrosis, rare kidney diseases, aging, and senescence
• Population-based Biobanks and high-quality, longitudinal genotype - phenotype data sets, including clinical and molecular data, access to biospecimens, and the potential for patient recall
• Computational Biology approaches to understand disease drivers through the integration of human omics data (e.g. genetics, RNA-seq, proteomics, epigenomics, clinical measures)
• AI/ML approaches for novel target and biomarker discovery, patient stratification, and methods of development for multi-omics data analysis and integration
• Novel in silico or in vitro approaches to translate disease associated genetic loci into causal genes and therapeutic hypotheses
• Functional Genomics technologies to accelerate target discovery in disease-relevant biological systems
• Breakthrough diagnostic technologies, including liquid biopsy testing and NGS panels in oncology, and near-patient rapid diagnostics testing in infectious diseases